Epstein barr virus and ms

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Med Hypotheses 91 — Mult Scler Relat Disord 16 :8— Hypothesis: Multiple sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons. Mult Scler Relat Disord 24 — Support Center Support Center. External link. Please review our privacy policy. Inflammatory damage to oligodendrocytes and stimulation of macrophages and microglia cells. By using our site, you acknowledge that you have read and understand our Privacy Policy and Terms of Use.

Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale More information: Kjetil Bjornevik et al, Longitudinal analysis reveals high prevalence of Epstein-Barr Virus associated with multiple sclerosis. DOI: Provided by Harvard T. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

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Load comments 0. This review examines the role of EBV in MS pathophysiology and summarizes the recent clinical and radiological findings, with a focus on B-cells and in vivo imaging.

Addressing the potential link between EBV and MS allows the better understanding of MS pathogenesis and helps to identify additional disease biomarkers that may be responsive to B-cell depleting intervention. Keywords: B-cells; Epstein-Barr virus; human endogeneous retrovirus-W; leptomeningeal contrast enhancement; magnetic resonance imaging; meningeal inflammation; mononucleosis; multiple sclerosis.

Abstract Multiple sclerosis MS is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage.